Research Article

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2013, 6(10): 745–751

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https://doi.org/10.1007/s12274-013-0352-4

Functionalization of high-moment magnetic nanodisks for cell manipulation and separation

Mingliang Zhang1, Christopher M. Earhart1, Chinchun Ooi1, Robert J. Wilson1, Mary Tang2, and Shan X. Wang1,2 ()

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1 476 Lomita Mall, Department of Materials Science and Engineering, Stanford University, Stanford 94305, USA
2 350 Serra Mall, Department of Electrical Engineering, Stanford University, Stanford 94305, USA

Keywords: cell separation, core–shell, functionalization, magnetic properties, nanotechnology
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Synthetic antiferromagnetic (SAF) nanoparticles are layer-structured particles with high single-particle magnetic moments. In order to covalently bind these nanoparticles to cells, they were coated with a silica shell followed by conjugation with streptavidin. The silica coating generates both SAF@SiO2 core–shell nanoparticles and silica core-free nanoparticles. Using a simple magnetic separation, silica nanoparticles were removed and SAF@SiO2 nanoparticles were purified. After streptavidin conjugation, these particles were used to stain lung cancer cells, making them highly magnetically responsive. The stained cells can rotate in response to an external magnetic field and can be captured when a blood sample containing these cells flows through the sifter.
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Functionalization of high-moment magnetic nanodisks for cell manipulation and separation. Nano Res. 2013, 6(10): 745–751 https://doi.org/10.1007/s12274-013-0352-4

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