Review Article


2013, 6(12): 853–870


A perspective on functionalizing colloidal quantum dots with DNA

Anirban Samanta, Zhengtao Deng, Yan Liu (), and Hao Yan ()

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Center for Single Molecule Biophysics, the Biodesign Institute & Department of Chemistry and Biochemistry, Arizona State University. Tempe, Arizona, 85281, USA
Present address: MIT, Synthetic Biology Center, Boston, MA, USA

Keywords: KEYWORDS colloidal quantum dots, semiconductor nanocrystals, DNA, conjugation, ligand exchange, covalent bond, core/shell
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ABSTRACT This perspective provides an overview of the techniques that have been developed for the conjugation of DNA to colloidal quantum dots (QDs), or semiconductor nanocrystals. Methods described include: ligand exchange at the QD surface, covalent conjugation of DNA to the QD surface ligands, and one-step DNA functionalization on core QDs or during core/shell QD synthesis in aqueous solution, with an emphasis on the most recent progress in our lab. We will also discuss emerging trends in DNA-functionalized QDs for potential applications.
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A perspective on functionalizing colloidal quantum dots with DNA. Nano Res. 2013, 6(12): 853–870

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