Research Article

|

2014, 7(6): 844–852

|

https://doi.org/10.1007/s12274-014-0445-8

Inhibitory activity of gold and silica nanospheres to vascular endothelial growth factor (VEGF)-mediated angiogenesis is determined by their sizes

Dong Hyun Jo1,2, Jin Hyoung Kim1, Jin Gyeong Son3,4, Yuanze Piao5, Tae Geol Lee3 (*), and Jeong Hun Kim1,2,6 (*)

View Author's information

1 Fight against Angiogenesis-Related Blindness (FARB) Laboratory, Clinical Research Institute, Seoul National University, Seoul, 110-744, Republic of Korea
2 Department of Biomedical Sciences, College of Medicine, Seoul National University, Seoul, 110-799, Republic of Korea
3 Center for Nano-Bio Convergence, World Class Laboratory, Korea Research Institute of Standards and Science, Daejeon, 305-340, Republic of Korea
4 Department of Chemistry and KI for the NanoCentury, KAIST, Daejeon, 305-701, Republic of Korea
5 Graduate School of Convergence Science and Technology, Seoul National University, Seoul 151-742 & Advanced Institutes of Convergence Technology, Suwon 443-270, Republic of Korea
6 Department of Ophthalmology, College of Medicine, Seoul National University, Seoul, 110-744, Republic of Korea

Keywords: nanospheres, anti-angiogenesis effects, inorganic nanoparticles, vascular endothelial growth factor, pathological angiogenesis
Full article PDF
Cite this article(Endnote)
Share this article
Metric

views: 157

Citations: 0

  • Abstract
  • References
  • Electronic Supplementary Material
Nanoparticles can be involved in biological activities such as apoptosis, angio- genesis, and oxidative stress by themselves. In particular, inorganic nanoparticles such as gold and silica nanoparticles are known to inhibit vascular endothelial growth factor (VEGF)-mediated pathological angiogenesis. In this study, we show that anti-angiogenic effect of inorganic nanospheres is determined by their sizes. We demonstrate that 20 nm size gold and silica nanospheres suppress VEGF-induced activation of VEGF receptor-2, in vitro angiogenesis, and in vivo pathological angiogenesis more efficiently than their 100 nm size counterparts. Our results suggest that modulation of the size of gold and silica nanospheres determines their inhibitory activity to VEGF-mediated angiogenesis.
Related Article
Cite this article

Inhibitory activity of gold and silica nanospheres to vascular endothelial growth factor (VEGF)-mediated angiogenesis is determined by their sizes. Nano Res. 2014, 7(6): 844–852 https://doi.org/10.1007/s12274-014-0445-8

Download citation