Research Article


2015, 8(3): 731–742


Bimetallic nano-mushrooms with DNA-mediated interior nanogaps for high-efficiency SERS signal amplification

Jianlei Shen1, Jing Su1, Juan Yan1, Bin Zhao1, Dongfang Wang1, Siyi Wang2, Kun Li1, Mengmeng Liu1, Yao He2, Sanjay Mathur3, Chunhai Fan1, and Shiping Song1,3 (*)

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1 Division of Physical Biology & Bioimaging Center, Shanghai Synchrotron Radiation Facility, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China
2 Institute of Functional Nano & Soft Materials (FUNSOM) and Jiangsu Key, Laboratory for Carbon-based Functional Materials & Devices, Soochow University, Suzhou 215123, China
3 Institute of Inorganic Chemistry, University of Cologne, D-50939 Cologne, Germany

Keywords: surface-enhanced Raman scattering, biometallic nanostructure, nano-mushroom, nanogap, gold nanoparticle
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Uniform silver-containing metal nanostructures with well-defined nanogaps hold great promise for ultrasensitive surface-enhanced Raman scattering (SERS) analyses. Nevertheless, the direct synthesis of such nanostructures with strong and stable SERS signals remains extremely challenging. Here, we report a DNA- mediated approach for the direct synthesis of gold–silver nano-mushrooms with interior nanogaps. The SERS intensities of these nano-mushrooms were critically dependent on the area of the nanogap between the gold head and the silver cap. We found that the formation of nanogaps was finely tunable by controlling the surface density of 6-carboxy-X-rhodamine (ROX) labeled single-stranded DNA (ssDNA) on the gold nanoparticles. We obtained nano-mushrooms in high yield with a high SERS signal enhancement factor of ~1.0 × 109, much higher than that for Au–Ag nanostructures without nanogaps. Measurements for single nano- mushrooms show that these structures have both sensitive and reproducible SERS signals.
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Bimetallic nano-mushrooms with DNA-mediated interior nanogaps for high-efficiency SERS signal amplification. Nano Res. 2015, 8(3): 731–742

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