Meng Li, Andong Zhao, Kai Dong, Wen Li, Jinsong Ren, and Xiaogang Qu (*)
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Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Changchun 130022, China
Polymerization of amyloid-β peptide (Aβ) into amyloid fibrils is a critical step in the pathogenesis of Alzheimer’s disease (AD). Inhibition of Aβ aggregation and destabilization of preformed Aβ fibrils have promising effects against AD and have been used in clinic trials. Herein, we demonstrate, for the first time, the application of WS2 nanosheets, to not only effectively inhibit Aβ aggregation, but also dissociate preformed Aβ aggregates upon near infrared (NIR) irradiation. Additionally, the biocompatible WS2 nanosheets possess the ability to cross the blood-brain barrier (BBB) to overcome the limitations of most previously reported Aβ inhibitors. Through van der Waals and electrostatic interactions between Aβ40 and WS2, Aβ40 monomers can be selectively adsorbed on the surface of the nanosheet to inhibit the Aβ40 aggregation process. Intriguingly, the unique high NIR absorption property of WS2 enables amyloid aggregates to be dissolved upon NIR irradiation. These results will promote biological applications of WS2 and provide new insight into the design of multifunctional nanomaterials for AD treatment.
Chemically exfoliated WS2 nanosheets efficiently inhibit amyloid β-peptide aggregation and can be used for photothermal treatment of Alzheimer’s disease. Nano Res. 2015, 8(10): 3216–3227 https://doi.org/10.1007/s12274-015-0821-z