Research Article

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2016, 9(3): 787–799

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https://doi.org/10.1007/s12274-015-0958-9

Facile synthesis of magnetic–plasmonic nanocomposites as T1 MRI contrast enhancing and photothermal therapeutic agents

Zhongzhen Yang1,2, Xianguang Ding1,2, and Jiang Jiang1 (*)

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1 Key Laboratory of Nano-Bio Interface, i-lab and Division of Nanobiomedicine, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou 215123, China
2 University of Chinese Academy of Sciences, Beijing 100049, China

Keywords: plasmonics, iron oxide, photothermal, T1, magnetic resonance imaging (MRI), theranostics
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  • Abstract
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Nanocomposites combining magnetic and plasmonic components have received widespread attention in recent years due to their potential applications in biomedical research. Herein, we describe a facile method for growing small iron oxide nanoparticles on various plasmonic core materials with different shapes and surfaces by utilizing a polypyrrole interlayer. By focusing on Au nanorod@polypyrrole@iron oxide (Au NR@PPy@FexO) nanocomposites, we show that these systems exhibit a low r2/r1 ratio of 4.8, making them efficient T1 positive contrast-enhancing agents for magnetic resonance imaging (MRI). Moreover, we show that the nanocomposites are excellent photothermal agents in the second near infrared region, with high photothermal conversion efficiency, reaching up to 46%. In addition, the Au NR@PPy@FexO nanocomposites show very low cytotoxicity. In summary, the present results highlight the great potential of the synthetic method and the nanocomposites developed in this study for T1 MRI and/or infrared thermal imaging-guided photothermal cancer therapeutic applications.
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Facile synthesis of magnetic–plasmonic nanocomposites as T1 MRI contrast enhancing and photothermal therapeutic agents. Nano Res. 2016, 9(3): 787–799 https://doi.org/10.1007/s12274-015-0958-9

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