Research Article

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2016, 9(5): 1236–1243

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https://doi.org/10.1007/s12274-016-1019-8

Photothermal therapy by using titanium oxide nanoparticles

Gang Ou1,§, Zhiwei Li2,§, Dongke Li1, Liang Cheng2, Zhuang Liu2 (*), and Hui Wu1 (*)

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1 State Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing
100084, China
2 Institute of Functional Nano & Soft Materials, Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow
University, Suzhou 215123, China
§ These authors contributed equally to this work.

Keywords: photothermal therapy, titanium oxides, biocompatibility, photothermal conversion
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ABSTRACT The photothermal therapy (PTT) technique is regarded as a promising method for cancer treatment. However, one of the obstacles preventing its clinical application is the non-degradability and biotoxicity of the existing heavy-metal and carbon-based therapeutic agents. Therefore, a PTT material with a high photothermal efficiency, low toxicity, and good biocompatibility is urgently wanted. Herein, we report a titanium oxide-based therapeutic agent with a high efficacy and low toxicity for the PTT process. We demonstrated that Magnéliphase Ti8O15 nanoparticles fabricated by the arc-melting method exhibit >98% absorption of near infrared light and a superior photothermal therapy effect in the in vivo mouse model. The Ti8O15 nanoparticle PTT material also shows a good biocompatibility and biosafety. Our study reveals Magnéli-phase titanium oxide as a new family of PTT agents and introduces new applications of titanium oxides for photothermal conversion.
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Photothermal therapy by using titanium oxide nanoparticles. Nano Res. 2016, 9(5): 1236–1243 https://doi.org/10.1007/s12274-016-1019-8

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