Gang Ou1,§, Zhiwei Li2,§, Dongke Li1, Liang Cheng2, Zhuang Liu2 (*), and Hui Wu1 (*)
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1 State Key Laboratory of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, China 2 Institute of Functional Nano & Soft Materials, Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou 215123, China § These authors contributed equally to this work.
The photothermal therapy (PTT) technique is regarded as a promising method
for cancer treatment. However, one of the obstacles preventing its clinical
application is the non-degradability and biotoxicity of the existing heavy-metal
and carbon-based therapeutic agents. Therefore, a PTT material with a high
photothermal efficiency, low toxicity, and good biocompatibility is urgently
wanted. Herein, we report a titanium oxide-based therapeutic agent with a high
efficacy and low toxicity for the PTT process. We demonstrated that Magnéliphase
Ti8O15 nanoparticles fabricated by the arc-melting method exhibit >98%
absorption of near infrared light and a superior photothermal therapy effect in
the in vivo mouse model. The Ti8O15 nanoparticle PTT material also shows a
good biocompatibility and biosafety. Our study reveals Magnéli-phase titanium
oxide as a new family of PTT agents and introduces new applications of titanium
oxides for photothermal conversion.