Research Article

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2016, 9(6): 1630–1638

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https://doi.org/10.1007/s12274-016-1057-2

Superfluorinated copper sulfide nanoprobes for simultaneous 19F magnetic resonance imaging and photothermal ablation

Gaofei Hu, Juan Tang, Xilin Bai, Suying Xu, and Leyu Wang (*)

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State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, China

Keywords: 19F magnetic resonanceimaging,photothermal therapy
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  • Abstract
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Copper sulfide (Cu7S4) nanoparticles coated with an ultra-high payload (~5.0 × 107fluorine atoms per particle) of fluorinated ligands (oleylamine functionalized3,5-bis(trifluoromethyl)benzaldehyde, 19FOAm) exhibited a single intense 19Fmagnetic resonance (MR) signal and efficient near infrared photothermalperformance in water medium. In vivo assessment revealed strong 19F MR signalsat cancerous lesions and effective inhibition of tumor growth after photothermaltreatment, indicating the great potential of these fabricated nanoprobes forsimultaneous 19F MR imaging and photothermal therapy.
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Superfluorinated copper sulfide nanoprobes for simultaneous 19F magnetic resonance imaging and photothermal ablation. Nano Res. 2016, 9(6): 1630–1638 https://doi.org/10.1007/s12274-016-1057-2

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