Research Article


2016, 9(8): 2520–2530


Fabrication of ultrathin Zn(OH)2 nanosheets as drug carriers

Ren Cai1, Dan Yang3, Jin Wu3, Liqin Zhang1, Cuichen Wu1, Xigao Chen1, Yanyue Wang1, Shuo Wan1, Fengwei Hou3, Qingyu Yan3, and Weihong Tan1,2 (*)

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1 Department of Chemistry and Department of Physiology and Functional Genomics, Center for Research at the Bio/Nano Interface, Shands Cancer Center, UF Genetics Institute, McKnight Brain Institute, University of Florida, Gainesville, FL 32611-7200, USA
2 Molecular Sciences and Biomedicine Laboratory, State Key Laboratory for Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering and College of Biology, Collaborative Innovation Center for Molecular Engineering and Theranostics, Hunan University, Changsha 410082, China
3 School of Materials Science and Engineering, Nanyang Technological University, Singapore 639798, Singapore

Keywords: aptamer,porous Zn(OH)2 nanosheets,cancer cell,cell-targeted delivery
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Ultrathin two-dimensional (2D) porous Zn(OH)2 nanosheets (PNs) were fabricatedby means of one-dimensional Cu nanowires as backbones. The PNs have thicknessof approximately 3.8 nm and pore size of 4–10 nm. To form “smart” porousnanosheets, DNA aptamers were covalently conjugated to the surface of PNs.These ultrathin nanosheets show good biocompatibility, efficient cellular uptake,and promising pH-stimulated drug release.
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Fabrication of ultrathin Zn(OH)2 nanosheets as drug carriers. Nano Res. 2016, 9(8): 2520–2530

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