Research Article


2017, 10(3): 767–775


Real-time electrical detection of epidermal skin MoS2 biosensor for point-of-care diagnostics

Geonwook Yoo1,§, Heekyeong Park2,§, Minjung Kim2,§, Won Geun Song2, Seokhwan Jeong2, Min Hyung Kim3, Hyungbeen Lee3, Sang Woo Lee3, Young Ki Hong2, Min Goo Lee4, Sungho Lee4 (*), and Sunkook Kim2 (*)

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1 School of Electronic Engineering, Soongsil University, Seoul 06978, Republic of Korea
2 Multi-Functional Nano/Bio Electronics Lab., Kyung Hee University, Gyeonggi 17104, Republic of Korea
3 Department of Biomedical Engineering, Yonsei University, Wonju 26493, Republic of Korea
4 Korea Electronics Technology Institute, Gyeonggi 13488, Republic of Korea
§ These authors contributed equally to this work.

Keywords: epidermal skin biomarker, MoS2, biosensor, real-time, point-of-care diagnostics
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ABSTRACT Various approaches have been proposed for point-of-care diagnostics, and in particular, optical detection is preferred because it is relatively simple and fast. At the same time, field-effect transistor (FET)-based biosensors have attracted great attention because they can provide highly sensitive and label-free detection. In this work, we present highly sensitive, epidermal skin-type point-of-care devices with system-level integration of flexible MoS2 FET biosensors, read-out circuits, and light-emitting diode (LEDs) that enable real-time detection of prostate cancer antigens (PSA). Regardless of the physical forms or mechanical stress conditions, our proposed high-performance MoS2 biosensors can detect a PSA concentration of 1 pg·mL–1 without specific surface treatment for anti-PSA immobilization on the MoS2 surface on which we characterize and confirm physisorption of anti-PSA using Kelvin probe force microscopy (KPFM) and tapping-mode atomic force microscopy (tm-AFM). Furthermore, current modulation induced by the binding process was stably maintained for longer than 2–3 min. The results indicate that flexible MoS2-based FET biosensors have great potential for point-of-care diagnostics for prostate cancer as well as other biomarkers.
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Real-time electrical detection of epidermal skin MoS2 biosensor for point-of-care diagnostics. Nano Res. 2017, 10(3): 767–775

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