Research Article

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2017, 10(3): 794–801

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https://doi.org/10.1007/s12274-016-1332-2

Small-molecule diketopyrrolopyrrole-based therapeutic nanoparticles for photoacoustic imaging-guided photothermal therapy

Yu Cai1,§, Weili Si1,§, Qianyun Tang1, Pingping Liang1, Chengwu Zhang1, Peng Chen2, Qi Zhang3 (*), Wei Huang1 (*), and Xiaochen Dong1 (*)

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1 Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation enter for Advanced Materials (SICAM), Nanjing Tech University (NanjingTech), 30 South Puzhu Road, Nanjing 211816, China
2 School of Chemical and Biomedical Engineering, Nanyang Technological University, 70 Nanyang Drive, N1.3-B3-08, Singapore School of Pharmaceutical Sciences, Nanjing Tech University (NanjingTech), 30 South Puzhu Road, Nanjing 211816, China
§ These authors contributed equally to this work.

Keywords: photothermal therapy, photoacoustic imaging, diketopyrrolopyrrole, donor–acceptor–donor
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ABSTRACT Therapeutic nanoparticles (NPs) based on the donor–acceptor–donor structured small organic molecule diketopyrrolopyrrole (SDPP) were prepared using a simple reprecipitation approach. These near-infrared radiation-absorbing NPs have high photothermal conversion efficiency and are able to selectively target cancer tissues through the enhanced permeability and retention effect. Benefiting from these advantages, SDPP NPs can serve as an excellent therapeutic agent for highly efficient and noninvasive photoacoustic imaging-guided photothermal therapy. Experiments using mouse tumor models showed that the SDPP NPs exhibited exceptional tumor ablation ability under laser irradiation (660 nm, 1.0 W·cm‒2), even at a low dose (0.16 mg·kg‒1).
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Small-molecule diketopyrrolopyrrole-based therapeutic nanoparticles for photoacoustic imaging-guided photothermal therapy. Nano Res. 2017, 10(3): 794–801 https://doi.org/10.1007/s12274-016-1332-2

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