Research Article

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2018, 11(5): 2436–2449

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https://doi.org/10.1007/s12274-017-1865-z

Polyethylene glycol-modified cobalt sulfide nanosheets for high-performance photothermal conversion and photoacoustic/magnetic resonance imaging

Zhenglin Li1,2,3, Zhuo Li1, Lei Chen4, Ying Hu5, Shaoshan Hu4, Zhaohua Miao6, Ye Sun2 (*), Flemming Besenbacher3 (*), and Miao Yu1 (*)

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1 State Key Laboratory of Urban Water Resource and Environment, School of Chemical Engineering and Technology, Harbin Institute of Technology, Harbin 150001, China
2 Condensed Matter Science and Technology Institute, Harbin Institute of Technology, Harbin 150001, China
3 Interdisciplinary Nanoscience Center (iNANO) and Department of Physics and Astronomy, Aarhus University, Aarhus 8000, Denmark
4 Department of Neurological Surgery, The Second Affiliated Hospital of the Harbin Medical University, Harbin 150001, China
5 School of Life Science and Technology, Harbin Institute of Technology, Harbin 150001, China
6 School of Materials Science and Engineering, Harbin Institute of Technology, Harbin 150001, China

Keywords: cobalt sulfide nanosheets, theranostic agent, photoacoustic imaging, magnetic resonance imaging, photothermal therapy
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ABSTRACT Theranostic nanoagents that integrate the diagnoses and therapies within a single nanomaterial are compelling in their use for highly precise and efficient antitumor treatments. Herein, polyethylene glycol (PEG)-modified cobalt sulfide nanosheets (CoS-PEG NSs) are synthesized and unitized as a powerful theranostic nanoagent for efficient photothermal conversion and multimodal imaging for the first time. We demonstrate that the obtained CoS-PEG NSs show excellent compatibility and stability in water and various physiological solutions, and can be effectively internalized by cells, but exhibit a low cytotoxicity. The CoS-PEG NSs exhibit an efficient photothermal conversion capacity, benefited from the strong near-infrared (NIR) absorption, high photothermal conversion efficiency (~33.0%), and excellent photothermal stability. Importantly, the highly effective photothermal killing effect on cancer cells after exposure to CoS-PEG NSs plus laser irradiation has been confirmed by both the standard Cell Counting Kit-8 and live-dead cell staining assays, revealing a concentration-dependent photothermal therapeutic effect. Moreover, utilizing the strong NIR absorbance together with the T2-MR contrast ability of the CoS-PEG NSs, a high-contrast triple-modal imaging, i.e., photoacoustic (PA), infrared thermal (IRT), and magnetic resonance (MR) imaging, can be achieved, suggesting a great potential for multimodal imaging to provide comprehensive cancer diagnosis. Our work introduces the first bioapplication of the CoS-PEG nanomaterial as a potential theranostic nanoplatform and may promote further rational design of CoS-based nanostructures for precise/efficient cancer diagnosis and therapy.
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Polyethylene glycol-modified cobalt sulfide nanosheets for high-performance photothermal conversion and photoacoustic/magnetic resonance imaging. Nano Res. 2018, 11(5): 2436–2449 https://doi.org/10.1007/s12274-017-1865-z

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