Review Article

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2018, 11(10): 5017–5027

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https://doi.org/10.1007/s12274-018-2093-x

Multifunctional nucleic acid nanostructures for gene therapies

Jianbing Liu1, Zhengang Wang1, Shuai Zhao1,2, and Baoquan Ding1,2 ()

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1 CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China 

2 University of Chinese Academy of Sciences, Beijing 100049, China

Keywords: nucleic acid nanostructure, nucleic acid drug, gene therapy, drug delivery, multifunctional nanomaterials
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  • Abstract
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ABSTRACT Nucleic acid nanotechnology has been developed to be a promising strategy to construct various nano-biomaterials with structural programmability, spatial addressability, and excellent biocompatibility. Self-assembled nucleic acid nanostructures have been employed in a variety of biomedical applications, such as bio-imaging, diagnosis, and therapeutics. In this manuscript, we will review recent progress in the development of multifunctional nucleic acid nanostructures as gene drug delivery vehicles. Therapeutic systems based on RNA interference (RNAi), clustered regularly interspaced short palindromic repeat associated proteins 9 system (CRISPR/Cas9) genome editing, gene expression, and CpG-based immunostimulation will be highlighted. We will also discuss the challenges and future directions of nucleic acid nanotechnology in biomedical research.
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Multifunctional nucleic acid nanostructures for gene therapies. Nano Res. 2018, 11(10): 5017–5027 https://doi.org/10.1007/s12274-018-2093-x

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