Research Article

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2019, 12(6): 1307–1312

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https://doi.org/10.1007/s12274-018-2242-2

Two-dimensional metal-organic-framework as a unique theranostic nano-platform for nuclear imaging and chemo-photodynamic cancer therapy

Wenjun Zhu1,§, Yu Yang2,§, Qiutong Jin1, Yu Chao1, Longlong Tian1, Jingjing Liu1, Ziliang Dong1, and Zhuang Liu1 (*)

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1 Institute of Functional Nano & Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices, Soochow University, Suzhou 215123, China
2 State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Avenida da Universidad, Taipa, Macau 31608, China
§ Wenjun Zhu and Yu Yang contributed equally to this work.

Keywords: nanoscale metal-organic-framework, two-dimensional nanosheets, drug delivery, photodynamic therapy, combination therapy
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  • Abstract
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Nanoscale metal organic frameworks (NMOFs) with porous structure and inherent biodegradability are attractive nanomedicine platforms. In addition to conventional particulate NMOFs, two-dimensional (2D) NMOFs are emerging as a unique type of NMOFs which however have been relatively less explored for nanomedicine applications. Herein, 2D-NMOFs composed of Zn2+ and tetrakis(4-carboxyphenyl) porphyrin (TCPP) are fabricated and functionalized with polyethylene glycol (PEG). Compared to their particulate counterpart, such 2D-NMOFs show greatly increased drug loading capacity and enhanced light-triggered singlet oxygen production, promising for chemotherapy and photodynamic therapy (PDT), respectively. Utilizing the porphyrin structure of TCPP, our 2D-NMOFs could be labeled with a diagnostic radioisotope, 99mTc, for single photon emission computer tomography (SPECT) imaging, which reveals efficient tumor homing of those 2D-NMOFs upon intravenous injection. While offering a remarkable synergistic in vivo antitumor effect for the combined chemo-PDT, such 2D-NMOFs show efficient biodegradation and rapid renal clearance. Our work presents the great promise of 2D-NMOFs for nanomedicine applications.
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Two-dimensional metal-organic-framework as a unique theranostic nano-platform for nuclear imaging and chemo-photodynamic cancer therapy. Nano Res. 2019, 12(6): 1307–1312 https://doi.org/10.1007/s12274-018-2242-2

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