Research Article

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2019, 12(4): 863–868

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https://doi.org/10.1007/s12274-019-2313-z

Bioengineered magnetoferritin nanozymes for pathological identification of high-risk and ruptured atherosclerotic plaques in humans

Tao Wang1,§, Jiuyang He2,3,§, Demin Duan3, Bing Jiang3, Peixia Wang3, Kelong Fan3, Minmin Liang3 (*), and Xiyun Yan3 (*)

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1 Department of Neurosurgery, Peking University Third Hospital, Beijing 100191, China
2 Savaid Medical School, University of Chinese Academy of Sciences, Beijing 100049, China
3 Key Laboratory of Protein and Peptide Pharmaceutical, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
§ Tao Wang and Jiuyang He contributed equally to this work.

Keywords: atherosclerosis, high-risk plaques, ruptured plaques, magnetoferritin nanoparticles, nanozymes, pathological diagnosis
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  • Abstract
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Atherosclerotic plaque rupture results in thrombus formation and vessel occlusion, and is the leading cause of death worldwide. There is a pressing need to identify plaque vulnerability for the treatment of carotid and coronary artery diseases. Nanomaterials with enzyme-like properties have attracted significant interest by providing biological, diagnostic and prognostic information about the diseases. Here we showed that bioengineered magnetoferritin nanoparticles (M-HFn NPs) functionally mimic peroxidase enzyme and can intrinsically recognize plaque-infiltrated active macrophages, which drive atherosclerotic plaque progression and rupture and are significantly associated with the plaque vulnerability. The M-HFn nanozymes catalyze the oxidation of colorimetric substrates to give a color reaction that visualizes the recognized active macrophages for one-step pathological identification of plaque vulnerability. We examined 50 carotid endarterectomy specimens from patients with symptomatic carotid disease and demonstrated that the M-HFn nanozymes could distinguish active macrophage infiltration in ruptured and high-risk plaque tissues, and M-HFn staining displayed a significant correlation with plaque vulnerability (r = 0.89, P < 0.0001).
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Bioengineered magnetoferritin nanozymes for pathological identification of high-risk and ruptured atherosclerotic plaques in humans. Nano Res. 2019, 12(4): 863–868 https://doi.org/10.1007/s12274-019-2313-z

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