Review Article

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2020, 13(7): 1810–1824

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https://doi.org/10.1007/s12274-020-2664-5

Progress in transdermal drug delivery systems for cancer therapy

Tianyue Jiang1, Guo Xu1, Guojun Chen2,3, Yu Zheng1, Bingfang He1 (*), and Zhen Gu2,3 (*)

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1 School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing 211816, China
2 Department of Bioengineering, University of California, Los Angeles, Los Angeles CA 90095, USA
3 Jonsson Comprehensive Cancer Center and California NanoSystems Institute, University of California, Los Angeles, Los Angeles CA 90095, USA

Keywords: drug delivery, transdermal delivery, cancer therapy, chemotherapy, immunotherapy, combination therapy
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  • Abstract
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Transdermal drug delivery is an appealing option except for oral and hypodermic administration. With the advancement of skin penetration strategies, various anticancer therapeutics ranging from lipophilic small-molecule drugs to hydrophilic biomacromolecules, can be administered transdermally, offering an optional regimen to treat skin cancers. In addition, the activation of the skin immune systems can also assist the treatment of distal sites. Current approaches on enhancing the transdermal delivery efficacy of anticancer drugs are summarized in this review. We also survey recent advances in micro- and nanotechnology-based transdermal formulations for cancer treatment, such as chemotherapy, gene therapy, immunotherapy, phototherapy and combination therapy. New penetration enhancers, materials, formulations and their hypothesized mechanisms for transdermal delivery are highlighted. Advantages and limitations regarding the state-of-the-art transdermal delivery technologies, as well as future perspective are also discussed.
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Progress in transdermal drug delivery systems for cancer therapy. Nano Res. 2020, 13(7): 1810–1824 https://doi.org/10.1007/s12274-020-2664-5

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