Research Article

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2020, 13(9): 2323–2331

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https://doi.org/10.1007/s12274-020-2783-z

Mesoporous silica rods with cone shaped pores modulate inflammation and deliver BMP-2 for bone regeneration

Chun Xu1,2,3, Lan Xiao4, Yuxue Cao1, Yan He1,5,6, Chang Lei7, Yin Xiao4, Wujin Sun2,3, Samad Ahadian2,3, Xueting Zhou8, Ali Khademhosseini2,3,9,10,11 (✉), and Qingsong Ye5,6,† (✉)

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1 School of Dentistry, The University of Queensland, Herston, QLD, 4006, Australia
2 Center for Minimally Invasive Therapeutics (C-MIT), University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA
3 Department of Bioengineering, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA
4 Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove Campus, Brisbane, 4006, Australia
5 School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou 325035, China
6 Department of Oral and Maxillofacial Surgery, Massachusetts General Hospital and Harvard School of Dental Medicine, Boston, MA 02114, USA
7 Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD 4072, Australia
8 Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA
9 Department of Chemical and Biomolecular Engineering, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA
10 Department of Radiological Sciences, University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA
11 Terasaki Institute for Biomedical Innovation, Los Angeles, CA, 90095, USA
Present address: Center of Regenerative Medicine, Renmin Hospital of Wuhan University, Wuhan University, Wuhan 430060, China

Keywords: mesoporous silica rod, bone regeneration, cone shaped pores, morphogenetic proteins 2 (BMP-2) delivery, osteoimmunomodulation
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  • Abstract
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Biomaterials with suitable osteoimmunomodulation properties and ability to deliver osteoinductive biomolecules, such as bone morphogenetic proteins, are desired for bone regeneration. Herein, we report the development of mesoporous silica rods with large cone-shaped pores (MSR-CP) to load and deliver large protein drugs. It is noted that those cone-shaped pores on the surface modulated the immune response and reduced the pro-inflammatory reaction of stimulated macrophage. Furthermore, bone morphogenetic proteins 2 (BMP-2) loaded MSR-CP facilitated osteogenic differentiation and promoted osteogenesis of bone marrow stromal cells. In vivo tests confirmed BMP-2 loaded MSR-CP improved the bone regeneration performance. This study provides a potential strategy for the design of drug delivery systems for bone regeneration.
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Mesoporous silica rods with cone shaped pores modulate inflammation and deliver BMP-2 for bone regeneration. Nano Res. 2020, 13(9): 2323–2331 https://doi.org/10.1007/s12274-020-2783-z

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