Research Article

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2020, 13(6): 1739–1748

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https://doi.org/10.1007/s12274-020-2800-2

Mesoporous PtPd nanoparticles for ligand-mediated and imagingguided chemo-photothermal therapy of breast cancer

Yanpeng Jia1,§, Yang Song3,§, Ying Qu1, Jinrong Peng1, Kun Shi1, Dan Du3, He Li2 (*), Yuehe Lin3 (*), and Zhiyong Qian1 (*)

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1 State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan Universityand Collaborative Innovation Center, Chengdu 610041, China
2 College of Optoelectronics Technology, Chengdu University of Information Technology, Chengdu 610225, China
3 School of Mechanical and Material Engineering, Washington State University, Pullman, WA 99163, USA
§ Yanpeng Jia and Yang Song contributed equally to this work.

Keywords: inorganic nanoparticles, photoacoustic imaging, porous structure, photothermal therapy, chemotherapy
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  • Abstract
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The synergistic therapy of chemotherapy and photothermal therapy (PTT) has been reported as a promising antitumor strategy. To achieve effective combination therapy, developing more suitable candidate nanomaterials with optimal photothermal property and high chemical drug loading capacity is very necessary. Herein, a bimetallic PtPd nanoparticle was synthesized with the merits of excellent photothermal effect and mesoporous structure for doxorubicin (DOX) loading. We further designed PtPd-ethylene glycol (PEG)-folic acid (FA)-doxorubicin (DOX) nanoparticle for chemo-photothermal therapy of MCF-7 tumor with folic acid engineering to achieve active targeting. Moreover, excellent photoacoustic (PA) imaging of PtPd-PEG-FA-DOX nanoparticles facilitated the precise in vivo tracking and further evaluation of nanoparticles’ targeting effect. The in vitro and in vivo results both demonstrated PtPd-PEG-FA-DOX nanoparticles serve as a safe and promising system for effective treatment of MCF-7 tumor.
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Mesoporous PtPd nanoparticles for ligand-mediated and imagingguided chemo-photothermal therapy of breast cancer. Nano Res. 2020, 13(6): 1739–1748 https://doi.org/10.1007/s12274-020-2800-2

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