Research Article


2020, 13(12): 3217–3223


In vitro study of enhanced photodynamic cancer cell killing effect by nanometer-thick gold nanosheets

Ziyi Zhang1,§, Dalong Ni2,3,§, Fei Wang1, Xin Yin1, Shreya Goel2, Lazarus N. German1, Yizhan Wang1, Jun Li1, Weibo Cai2,3 (✉), and Xudong Wang1 (✉)

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1 Department of Materials Science and Engineering, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA
2 Department of Radiology, University of Wisconsin-Madison, Madison, Wisconsin 53705, USA
3 University of Wisconsin Carbone Cancer Center, Madison, Wisconsin 53705, USA
§ Ziyi Zhang and Dalong Ni contributed equally to this work.

Keywords: gold nanosheet, ionic layer epitaxy, surface plasmon, photodynamic effect, cancer therapy
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Photodynamic therapy (PDT) by near-infrared (NIR) irradiation is a promising technique for treating various cancers. Here, we reported the development of free-standing wafer-scale Au nanosheets (NSs) that exhibited an impressive PDT effect. The Au NSs were synthesized by ionic layer epitaxy at the air-water interface with a uniform thickness in the range from 2 to 8.5 nm. These Au NSs were found very effective in generating singlet oxygen under NIR irradiation. In vitro cellular study showed that the Au NSs had very low cytotoxicity and high PDT efficiency due to their uniform 2D morphology. Au NSs could kill cancer cells after 5 min NIR irradiation with little heat generation. This performance is comparable to using 10 times mass loading of Au nanoparticles (NPs). This work suggests that two-dimensional (2D) Au NSs could be a new type of biocompatible nanomaterial for PDT of cancer with an extraordinary photon conversion and cancer cell killing efficiency.
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In vitro study of enhanced photodynamic cancer cell killing effect by nanometer-thick gold nanosheets. Nano Res. 2020, 13(12): 3217–3223

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