Research Article


2020, 13(12): 3364–3370


Multifunctional shape-dependent plasmonic nanoprobe by enzymatic etching of single gold triangular nanoplate

Ning Feng1,§, Jingjing Shen1,§, Yu Chen1, Chang Li1, Yanling Hu1,2, Lei Zhang1 (✉), Shufen Chen1, Quli Fan1, Wei Huang1,3, and Lianhui Wang1 (✉)

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1 Key Laboratory for Organic Electronics and Information Displays and Institute of Advanced Materials (IAM), Nanjing University of Posts and Telecommunications, 9 Wenyuan Road, Nanjing 210023, China
2 School of Electrical and Control, Nanjing Polytechnic Institute, 188 Xinle Road, Nanjing 211500, China
3 Frontiers Science Center for Flexible Electronics (FSCFE), Shaanxi Institute of Flexible Electronics (SIFE) and Shaanxi Institute of Biomedical Materials and Engineering (SIBME), Northwestern Polytechnical University (NPU), 127 West Youyi Road, Xi'an 710072, China
§ Ning Feng and Jingjing Shen contributed equally to this work.

Keywords: gold triangular nanoprisms, enzymatic etching, plasmonic, H2O2 detection, logic operations
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  • Abstract
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Hydrogen peroxide (H2O2), as a signaling molecule, plays a vital role in a wide variety of signaling transduction processes, aging, and diseases. However, the excessive production of H2O2 causes various diseases. Herein, we develop a novel method for H2O2 detection in live cells via dark-field scattering spectroscopy with gold triangular nanoprisms (AuTNPs) as probes. The corners of AuTNPs would be gradually oxidatively etched by the strong coordination of Br• which is generated by enzymatic reactions in the presence of horseradish peroxidase (HRP), bromide ion and trace hydrogen peroxide. Benefitting from the morphological change, the single AuTNP based plasmonic nanoprobe shows notable blueshifts and scattering color changes which could be real-time monitored under the dark-field microscopy. The peak position in the scattering spectra of individual AuTNP blueshifts linearly with the increase of H2O2 concentration, and exhibits high sensitivity to H2O2 in a large range from 2.5 to 100 μM with a low detection limit (LOD) of 0.74 μM. Moreover, the experimental results were supported by the simulated results via the finite-difference time-domain (FDTD) method. The nanoprobes have been further used for intracellular H2O2 detection in live cells. Besides, the etching of AuTNP also provides an alternative method to design novel plasmonic logic chips and write-once plasmonic memories.
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Multifunctional shape-dependent plasmonic nanoprobe by enzymatic etching of single gold triangular nanoplate. Nano Res. 2020, 13(12): 3364–3370

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