Research Article

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2021, 14(12): 4577–4583

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https://doi.org/10.1007/s12274-021-3376-1

Polydopamine functionalized mesoporous silica as ROS-sensitive drug delivery vehicles for periodontitis treatment by modulating macrophage polarization

Bingbing Bai1,§, Chaoyu Gu2,§, Xiaohui Lu1,§, Xingyu Ge3, Junling Yang2, Chenfei Wang1, Yongchun Gu4, Aidong Deng2, Yuehua Guo2 (✉), Xingmei Feng1 (✉), and Zhifeng Gu3 (✉)

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1 Department of Stomatology, Affiliated Hospital of Nantong University, Nantong 226001, China
2 Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, Nantong 226001, China
3 Department of Rheumatology, Affiliated Hospital of Nantong University, Nantong 226001, China
4 Department of Stomatology, Suzhou Ninth People’s Hospital, Suzhou 215200, China
§ Bingbing Bai, Chaoyu Gu, and Xiaohui Lu contributed equally to this work.

Keywords: periodontitis, drug delivery, reactive oxygen species, macrophage polarization, inflammatory microenvironment
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  • Abstract
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Periodontitis is recognized as the major cause of tooth loss in adults, posing an adverse impact on systemic health. In periodontitis, excessive production of reactive oxygen species (ROS) at the inflamed site culminates in periodontal destruction. In this study, a novel ROS-responsive drug delivery system based on polydopamine (PDA) functionalized mesoporous silica nanoparticles was developed for delivering minocycline hydrochloride (MH) to treat periodontitis. The outer PDA layer and the inner MH of the nanoparticles acted as ROS scavengers and anti-inflammatory agents, respectively. Under the synergistic action of PDA and MH, macrophages were polarized from the pro-inflammatory M1 to the anti-inflammatory M2 phenotype. The in vitro experiments provided convincing evidence that PDA could scavenge ROS effectively, and the expression of pro-inflammatory cytokines was attenuated and the secretion of anti-inflammatory cytokines was enhanced through M1 to M2 polarization of macrophages with the cooperation of MH. In addition, the results obtained from the periodontitis rat models demonstrated that the synergetic effect of PDA and MH prevented alveolar bone loss without causing any adverse effect. Taken together, the results from the present investigation provide a new strategy to remodel the inflammatory microenvironment by inducing the polarization of macrophages from M1 toward M2 state for the treatment of periodontitis.
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Polydopamine functionalized mesoporous silica as ROS-sensitive drug delivery vehicles for periodontitis treatment by modulating macrophage polarization. Nano Res. 2021, 14(12): 4577–4583 https://doi.org/10.1007/s12274-021-3376-1

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