Research Article

|

2021, 14(12): 4689–4695

|

https://doi.org/10.1007/s12274-021-3406-z

Synergistic effect enhances the peroxidase-like activity in platinum nanoparticle-supported metal–organic framework hybrid nanozymes for ultrasensitive detection of glucose

Jing Li1, Jie Zhao1, Shengqiang Li3, Yang Chen1, Weiqiang Lv4, Jiahui Zhang1, Libing Zhang1, Zhen Zhang1 (✉), and Xiaoquan Lu1,2 (✉)

View Author's information

1 Tianjin Key Laboratory of Molecular Optoelectronic, Department of Chemistry, School of Science, Tianjin University, Tianjin 300072, China
2 Key Laboratory of Bioelectrochemistry & Environmental Analysis of Gansu Province, College of Chemistry & Chemical Engineering, Northwest Normal University, Lanzhou 730070, China
3 First Teaching Hospital of Tianjin University of Traditional Chinese Medicine Tianjin 300000, China
4 School of Physics, University of Electronic Science and Technology, Chengdu 611731, China

Keywords: metal–organic frameworks, Pt nanoparticles, synergistic effect, glucose detection
Full article PDF
Cite this article(Endnote)
Share this article
Metric

views: 144

Citations: 0

  • Abstract
  • References
  • Electronic Supplementary Material
The metal–organic frameworks (MOFs) are expected as ideal biomimetic enzymes for colorimetric glucose detection because of their large surface areas, well defined pore structures, tunable chemical composition, and multi-functional sites. However, the intrinsically chemical instability and low mimetic enzyme activity of MOFs hinder the application of them in imitating the enzyme reactions. In this work, we demonstrated a metal-MOF synergistic catalysis strategy, by loading Pt nanoparticles (Pt NPs) on MIL-88B-NH2 (Fe-MOF) to increase peroxidase-like activity for the detection of glucose. The induced electrons transfer from Pt atom to Fe atom accelerated the redox cycling of Fe3+/Fe2+, improved the overall efficiency of the peroxidase-like reaction, and enabled the efficient and robust colorimetric glucose detection, which was proved by both experiments and density functional theory (DFT) calculation. Additionally, the sensitivity and chemical stability of this synergistic effect strategy to detect the glucose are not affected by the complex external factors, which represented a great potential in fast, easy, sensitive, and specific recognition of clinical diabetes.
Related Article
Cite this article

Synergistic effect enhances the peroxidase-like activity in platinum nanoparticle-supported metal–organic framework hybrid nanozymes for ultrasensitive detection of glucose. Nano Res. 2021, 14(12): 4689–4695 https://doi.org/10.1007/s12274-021-3406-z

Download citation