Review Article


2021, 14(9): 2981–3009


Metal-organic frameworks as functional materials for implantable flexible biochemical sensors

Ya Li1,§, Wei Ling1,§, Xinyu Liu1, Xue Shang1, Pan Zhou1, Zhaorun Chen1, Hang Xu1, and Xian Huang1,2 (✉)

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1 Department of Biomedical Engineering, Tianjin University, Tianjin 300072, China
2 Center of Flexible Wearable Technology, Institute of flexible electronic technology of Tsinghua, Jiaxing 314006, China
§ Ya Li and Wei Ling contributed equally to this work.

Keywords: flexible electronics, metal-organic frameworks, biosensors, chemical sensing, implantable devices
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  • Abstract
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Metal-organic frameworks (MOFs) exhibit attractive properties such as highly accessible surface area, large porosity, tunable pore size, and built-in redox-active metal sites. They may serve as excellent candidates to construct implantable flexible devices for biochemical sensing due to their high thermal and solution stability. However, MOFs-based sensors have only been mostly reported for in-vitro chemical sensing, their use in implantable chemical sensing and combination with flexible electronics to achieve excellent mechanical compatibility with tissues and organs has rarely been summarized. This paper systematically reviews the biochemical sensors based on MOFs and discusses the feasibility to achieve implantable biochemical sensing through MOFsbased flexible electronics. The properties of MOFs and underlying mechanisms have been introduced, followed by a summarization of different biochemical sensing applications. Strategies to integrate MOFs with flexible devices have been supplied from the standpoints of matching mechanics and compatible fabrication processes. Issues that should be addressed in developing flexible MOFs sensors and potential solutions have also been provided, followed by the perspective for future applications of flexible MOFs sensors. This paper may serve as a reference to offer potential guidelines for the development of flexible MOFs-based biochemical sensors that may benefit future applications in personal healthcare, disease diagnosis and treatment, and fundamental study of various biological processes.
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Metal-organic frameworks as functional materials for implantable flexible biochemical sensors. Nano Res. 2021, 14(9): 2981–3009

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