Flagship Review

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2022, 15(1): 1–17

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https://doi.org/10.1007/s12274-021-3546-1

Adaptive iron-based magnetic nanomaterials of high performance for biomedical applications

Ning Gu1,2,3 (✉), Zuoheng Zhang1,2, and Yan Li1,2

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1 State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China
2 Collaborative Innovation Center of Suzhou Nano-Science and Technology, Suzhou Key Laboratory of Biomaterials and Technologies, Suzhou 215123, China
3 School of Biomedical Engineering and Informatics, Nanjing Medical University, Nanjing 211166, China

Keywords: magnetic nanomaterials, high performance, performance regulation, controllable assembly, biomedical applications
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  • Abstract
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With unique physicochemical properties and biological effects, magnetic nanomaterials (MNMs) play a crucial role in the biomedical field. In particular, magnetic iron oxide nanoparticles (MIONPs) are approved by the United States Food and Drug Administration (FDA) for clinical applications at present due to their low toxicity, biocompatibility, and biodegradability. Despite the unarguable effectiveness, massive space for improving such materials’ performance still needs to be filled. Recently, many efforts have been devoted to improving the preparation methods based on the materials’ biosafety. Besides, researchers have successfully regulated the performance of magnetic nanoparticles (MNPs) by changing their sizes, morphologies, compositions; or by aggregating as-synthesized MNPs in an orderly arrangement to meet various clinical requirements. The rise of cloud computing and artificial intelligence techniques provides novel ways for fast material characterization, automated data analysis, and mechanism demonstration. In this review, we summarized the studies that focused on the preparation routes and performance regulations of high-quality MNPs, and their special properties applied in biomedical detection, diagnosis, and treatment. At the same time, the future development of MNMs was also discussed.
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Adaptive iron-based magnetic nanomaterials of high performance for biomedical applications. Nano Res. 2022, 15(1): 1–17 https://doi.org/10.1007/s12274-021-3546-1

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