Flagship Review

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2022, 15(2): 739–757

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https://doi.org/10.1007/s12274-021-3595-5

Hollow structures as drug carriers: Recognition, response, and release

Decai Zhao1,2, Nailiang Yang1,2 (✉), Lekai Xu1,3, Jiang Du3, Yang Yang4,5 (✉), and Dan Wang1,2 (✉)

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1 State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China
2 University of Chinese Academy of Sciences, Beijing 100049, China
3 Green Catalysis Center, and College of Chemistry, School of Materials Science and Engineering, Zhengzhou University, Zhengzhou 450001 China
4 Department of Thoracic Surgery, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai 200433, China
5 School of Materials Science and Engineering, Tongji University, Shanghai 201804, China

Keywords: hollow structure, drug delivery system, carriers, spatiotemporal
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  • Abstract
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Hollow structures have demonstrated great potential in drug delivery owing to their privileged structure, such as high surfaceto-volume ratio, low density, large cavities, and hierarchical pores. In this review, we provide a comprehensive overview of hollow structured materials applied in targeting recognition, smart response, and drug release, and we have addressed the possible chemical factors and reactions in these three processes. The advantages of hollow nanostructures are summarized as follows: hollow cavity contributes to large loading capacity; a tailored structure helps controllable drug release; variable compounds adapt to flexible application; surface modification facilitates smart responsive release. Especially, because the multiple physical barriers and chemical interactions can be induced by multishells, hollow multishelled structure is considered as a promising material with unique loading and releasing properties. Finally, we conclude this review with some perspectives on the future research and development of the hollow structures as drug carriers.
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Hollow structures as drug carriers: Recognition, response, and release. Nano Res. 2022, 15(2): 739–757 https://doi.org/10.1007/s12274-021-3595-5

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