Research Article


2021, 14(12): 4644–4649


Polymersome formation by solvent annealing-induced structural reengineering under 3D soft confinement

Xi Mao1, Hao Li1, Jinwoo Kim2, Shuai Deng1, Renhua Deng1 (✉), Bumjoon J. Kim2, and Jintao Zhu1 (✉)

View Author's information

1 Key Laboratory of Material Chemistry for Energy Conversion and Storage of Ministry of Education (HUST), and State Key Laboratory of Materials Processing and Die & Mold Technology, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology (HUST), Wuhan 430074, China
2 Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea

Keywords: polymersome, block copolymer, three-dimensional (3D) confinement, self-assembly, solvent annealing
Full article PDF
Cite this article(Endnote)
Share this article

views: 48

Citations: 0

  • Abstract
  • References
  • Electronic Supplementary Material
A solvent annealing-induced structural reengineering approach is exploited to fabricate polymersomes from block copolymers that are hard to form vesicles through the traditional solution self-assembly route. More specifically, polystyrene-b-poly(4-vinyl pyridine) (PS-b-P4VP) particles with sphere-within-sphere structure (SS particles) are prepared by three-dimensional (3D) soft-confined assembly through emulsion-solvent evaporation, followed by 3D soft-confined solvent annealing upon the SS particles in aqueous dispersions for structural engineering. A water-miscible solvent (e.g., THF) is employed for annealing, which results in dramatic transitions of the assemblies, e.g., from SS particles to polymersomes. This approach works for PS-b-P4VP in a wide range of block ratios. Moreover, this method enables effective encapsulation/loading of cargoes such as fluorescent dyes and metal nanoparticles, which offers a new route to prepare polymersomes that could be applied for cargo release, diagnostic imaging, and nanoreactor, etc.
Related Article
Cite this article

Polymersome formation by solvent annealing-induced structural reengineering under 3D soft confinement. Nano Res. 2021, 14(12): 4644–4649

Download citation