Volume 11

Issue 10,2018

(46 articles)


Song Ih Ahn1,2,§, Hyun-Ji Park1,§, Jiwon Yom1,2, Taeyoung Kim1, and Yong Tae Kim1,2,3,4 (*)

This review introduces the heterogeneous characteristics and biological functions of high-density lipoproteins (HDLs), highlights the current representative applications of HDL mimetic nanotherapeutics for cardiovascular and neurodegenerative diseases, and discusses the current challenges and future perspective.
2018, 11(10): 5130–5143
Published: 8 June 2018

Jackson T. Del Bonis-O’Donnell1, Linda Chio1, Gabriel F. Dorlhiac2, Ian R. McFarlane1, and Markita P. Landry1,3,4,5 (*

Nanomaterials are providing new insights into the structure and function of the brain. In this review, we summarize the different techniques used in optical microscopy and discuss recent advances in nanomaterials, which are enabling new methods for visualizing the living brain.
2018, 11(10): 5144–5172
Published: 8 August 2018

Kyuri Lee§, Minjeong Kim§, Yunmi Seo, and Hyukjin Lee (*)

In this article, the recent progresses of messenger RNA (mRNA) vaccines for applications in prophylactic and therapeutic vaccines are explained. It provides an overview of two types of mRNA vaccines (conventional mRNA vaccines, self-amplifying mRNA vaccines) and their prophylactic applications to prevent future virus infections. In addition, therapeutic applications of mRNA vaccines in cancer immunotherapy are described with a brief introduction to cancer immunotherapy.
2018, 11(10): 5173–5192
Published: 31 May 2018

Boyang Sun1,2, Robert M. Straubinger3, and Jonathan F. Lovell1,2 (*)

Although first-generation taxanes (i.e. paclitaxel and docetaxel) have sparked broad interest in a variety of promising delivery vehicles, fewer have yet been developed for cabazitaxel, second generation taxane. This review summarizes several clinical-stage approaches for taxane formulation, and recent efforts to develop novel cabazitaxel delivery systems.
2018, 11(10): 5193–5218
Published: 30 August 2018

Rimpei Kamegawa1, Mitsuru Naito2, and Kanjiro Miyata1 (*)

This review discusses the functionalization and performance of silica nanoparticles for nucleic acid delivery with respect to loading and programmed release of nucleic acids, active targeting, endosome escape, and biocompatibility.
2018, 11(10): 5219–5239
Published: 27 June 2018

Teng Li, He Dong, Can Zhang (), and Ran Mo ()

This review presents recent advances in biomedical applications of cell-based drug delivery systems with a focus on drug delivery, tissue engineering,bioimaging,and disease treatment.
2018, 11(10): 5240–5257
Published: 3 September 2018

Xu Zhen and Kanyi Pu ()

This review summarizes the development of optical nanoprobes that emit near-infrared (NIR) fluorescent, upconversion luminescent (UCL), chemiluminescent (CL), or photoacoustic (PA) signals for molecular imaging of reactive oxygen and nitrogen species (RONS) in living systems.
2018, 11(10): 5258–5280
Published: 6 July 2018

Qingqing Xiong1,2, Gha Young Lee1, Jianxun Ding1, Wenliang Li1,3, and Jinjun Shi1 (*)

Along with the development of chemical modification strategies and nanotechnology delivery platforms, mRNA nanomedicine has recently shown increasingly widespread biomedical applications including vaccination, protein-replacement therapy, gene editing, and cellular reprogramming and engineering.
2018, 11(10): 5281–5309
Published: 27 July 2018

Jason B. Miller1,2 and Daniel J. Siegwart1,2 ()

This review describes the design of synthetic nanomaterials with clinical utility to deliver RNA cargos including small RNA (siRNA/ miRNA), messenger RNA, and RNAs for non-viral CRISPR/Cas gene editing.
2018, 11(10): 5310–5337
Published: 7 August 2018

Lu Tan and Xun Sun ()

Appropriate delivery systems can improve the limited stability, poor translation efficiency, and cell targeting of messenger RNA (mRNA) vaccines.
2018, 11(10): 5338–5354
Published: 26 May 2018