Volume 11

Issue 10,2018

(46 articles)


Wenjing Qi1, Yufei Zhang1, Zdravko Kochovski2, Jue Wang1, Yan Lu2,3, Guosong Chen1 (*), and Ming Jiang1

Human Galectin was found to be able to form protein microribbons by protein–carbohydrate interactions and the dimerization of Rhodamine B (RhB). These protein microribbons could multivalently and dynamically compete with accommodate the binding between Human Galectin-1 (Gal-1) and cell receptors and inhibit T-cell agglutination and apoptosis.
2018, 11(10): 5566–5572
Published: 28 August 2018

Zhiyuan Fan1,§, Peter Y. Li1,§, Junjie Deng1,2, Stephen C. Bady1, and Hao Cheng1 (*)

Incorporation of therapeutic-releasing nanoparticles into biomaterial scaffolds has broad applications in tissue regeneration and immune modulation, but may induce excessive inflammatory and foreign body responses to scaffold constructs, limiting their applications. We report a new strategy to harness the natural biocompatibility of cell membranes to eliminate acute inflammatory responses by coating nanoparticle surfaces with red blood cell membranes.
2018, 11(10): 5573–5583
Published: 12 May 2018

Jonathan Wang1, Christopher Poon1, Deborah Chin1, Sarah Milkowski1, Vivian Lu1, Kenneth R. Hallows2,3, and Eun Ji Chung1,2,4,5,6 (*)

Kidney-targeting multimodal micelles demonstrate enhanced accumulation compared to untargeted controls. Analysis of nanoparticle distribution show tubular cell colocalization within the nephron of the kidney.
2018, 11(10): 5584–5595
Published: 6 June 2018

Xiao Luo1, Weiyu Zhao1, Bin Li1, Xinfu Zhang1, Chengxiang Zhang1, Anna Bratasz2, Binbin Deng3, David W. McComb3, and Yizhou Dong1,4,5,6,7,8 (*)

Messenger RNA (mRNA) and superparamagnetic iron oxide nanoparticles (SPIONs) were co-encapsulated into amino-ester nanomaterials,which displayed dual functions both in vitro and in vivo.
2018, 11(10): 5596–5603
Published: 12 May 2018

Yichuan Guo1,2, Zhiqiang Fang3, Mingde Du1,2, Long Yang4, Leihou Shao1,2, Xiaorui Zhang1,2, Li Li1,2, Jidong Shi1,2, Jinsong Tao3, Jinfen Wang1,2, Hongbian Li1,2 (*), and Ying Fang1,2,5 (*)

Flexible and biocompatible neural electrode arrays based on a nanopaper substrate have been developed. These electrode arrays exhibit high sensitivity and stability in long-term brain activity recording.
2018, 11(10): 5604–5614
Published: 9 February 2018

Huahua Song1,§, Xinyi Ma1,§, Jianrong Xu1,§, Qingxiang Song1, Meng Hu1,3, Xiao Gu1, Qian Zhang1, Lina Hou1, Lepei Chen1, Yukun Huang2, Ping Yu1, Dayuan Wang1, Gan Jiang1, Meng Huang1, Jun Chen2, Hongzhuan Chen1 (*), and Xiaoling Gao1 (*)

Here, we constructed two discoidal reconstituted high-density lipoprotein (rHDL) nanocarriers (d-rHDL and d-GM1-rHDL) and two spherical rHDL nanocarriers (s-rHDL and s-GM1-rHDL) and for the first time demonstrated the shape effect of rHDL nanocarriers on their brain delivery and amyloid β clearance capacity.
2018, 11(10): 5615–5628
Published: 11 June 2018

Xiaoyuan Ji§, Daoxia Guo§, Bin Song, Sicong Wu, Binbin Chu, Yuanyuan Su, and Yao He (*)

A novel TCM-assisted chemical synthetic strategy is introduced for the one-pot synthesis of small-sized water-dispersed AC-SiNPs, which simultaneously possess robust fluorescence, excellent storage stability, and more interestingly, intrinsic anti-cancer efficacy with good selectivity towards cancer cells. Furthermore, the as-prepared AC-SiNPs are further employed for synergistic fluorescence bioimaging and treatment of tumors.
2018, 11(10): 5629–5641
Published: 6 February 2018

Shannon J. Tsai1, James I. Andorko1, Xiangbin Zeng1, Joshua M. Gammon1, and Christopher M. Jewell1,2,3,4,5 (*)

The interaction strength within polyplexes between a molecular adjuvant (CpG) and a degradable polycation (poly (β-amino ester), PBAE) is dependent on the ratio of these components during assembly. The interaction strength impacts the uptake and processing of the CpG, and the resulting immune response during activation of antigen presenting cells, expansion of tumor-specific T cells, and tumor immunotherapy.
2018, 11(10): 5642–5656
Published: 13 September 2018

Qian Chen1 , Jiawen Chen1 , Zhijuan Yang1 , Lin Zhang2 , Ziliang Dong1 , and Zhuang Liu1 (*)

A new type of photosensitizing nano-agent that simultaneously enables in vivo fluorescence imaging, tumor hypoxia relief, and the second near-infrared window (NIR-II) light-induced in vivo photodynamic therapy (PDT) of cancer was developed.
2018, 11(10): 5657–5669
Published: 10 November 2017

Andrea Joseph1, Thomas Wood2, Chih-Chung Chen1,, Kylie Corry2, Jessica M. Snyder3, Sandra E. Juul2, Pratik Parikh2, and Elizabeth Nance1,4 (*)

Curcumin-loaded brain-penetrating nanoparticles can cross the impaired blood-brain barrier following systemic administration in a neonatal hypoxia-ischemia rat model. The brain-penetrating nanoparticles localize in regions of injury and release curcumin to provide a neuroprotective effect, expanding the number of clinically-relevant therapeutic interventions for the treatment of neonatal hypoxic-ischemic encephalopathy.
2018, 11(10): 5670–5688
Published: 8 June 2018