Volume 11

Issue 10,2018

(46 articles)

Contents(PDF)

Sean D. Allen1, Yu-Gang Liu2, Sharan Bobbala2, Lei Cai3, Peter I. Hecker3,4, Ryan Temel3,4, and Evan A. Scott1,2 (*)

Poly (ethylene glycol)-block-poly (propylene sulfide)(PEG-bl-PPS) polymersomes formed by flash nanoprecipitation were found to be non-toxic after repeated intravenous administration in non-human primates. Polymersomes were taken up by antigen-presenting cell subsets in the liver, kidneys, and spleen of treated cynomolgus monkeys.
https://doi.org/10.1007/s12274-018-2069-x
2018, 11(10): 5689–5703
Published: 28 April 2018

Luying Wang1,3, Pingqiang Cai4, Jing Luo2,3, Feilong Zhang1,3, Jian Liu2, Yupeng Chen2,3, Zhongpeng Zhu2,3, Yongyang Song2,3, Bingquan Yang2, Xi Liu2,3, Xiaodong Chen4, and Shutao Wang2,3 (*)

Subcellular-patterned biointerfaces were employed to inhibit the surface wetting of multicellular spheroids.
https://doi.org/10.1007/s12274-018-2117-6
2018, 11(10): 5704–5715
Published: 22 June 2018

Wei Jiang1, Jilong Wang2, Jinbin Yang3, Zhiwei He4, Zhenhui Hou4, Yingli Luo2, Li Wang2, Jing Liu2, Houbing Zhang1, Yangyang Zhao2, Guoqing Zhang1, Fang Huang4, Xuechang Zhou3, Lifeng Yan1 (*), Xianzhu Yang5 (*), Yucai Wang2 (*), and Jun Wang5

A transactivator of transcription (TAT)-presenting nanomedicine, apart from improving tumor accumulation and cellular uptake, can simultaneously enhance tumor retention and promote nuclear translocation of the encapsulated platinum prodrugs, and thus improve therapeutic efficacy.
https://doi.org/10.1007/s12274-017-1925-4
2018, 11(10): 5716–5734
Published: 3 October 2018

M. Zubair Iqbal1, Wenzhi Ren1, Madiha Saeed1, Tianxiang Chen1, Xuehua Ma1, Xu Yu1, Jichao Zhang2, Lili Zhang2, Aiguo Li2, and Aiguo Wu1 (*)

A unique liquid-phase method was employed to fabricate Mn3O4- TiO2/ZnO/Fe3O4 multifunctional binary transition metal oxide-based Janus nanoparticles, using the concept of epitaxial growth and lattice mismatch among synthesized materials. These multifunctional Mn3O4-TiO2 Janus nanoparticles enhance T1-weighted magnetic resonance imaging contrast in the heart, liver, and kidneys and show excellent tumor ablation in photodynamic therapy.
https://doi.org/10.1007/s12274-017-1628-x
2018, 11(10): 5735–5750
Published: 3 October 2018

Trever Todd1,§, Zhenhui Lu2,§, Jinmin Zhao2,§, Benjamin Cline1, Weizhong Zhang1, Hongmin Chen1,3, Anil Kumar1, Wen Jiang1, Franklin West4, Samuel Franklin5, Li Zheng2 (*), and Jin Xie1 (*)

Controlled lithium delivery for efficient osteoarthritis therapy is described. We use a LiF nanocrystal as a lithium reservoir, silica coating to control the lithium release rate, and hyaluronic acid as the delivery medium. The sustained lithium release elicits broad inhibition of osteoarthritis-related catabolic markers, leading to effective protection of cartilage.
https://doi.org/10.1007/s12274-018-2061-5
2018, 11(10): 5751–5760
Published: 14 April 2018

Weiqiang Zhou1,2, Hongfeng Li1, Bin Xia1, Wenlan Ji1, Shaobo Ji2, Weina Zhang1, Wei Huang1(*), Fengwei Huo1(*), and Huaping Xu2 (*)

A general and facile method to fabricate efficient glutathione peroxidase (GPx) mimics has been developed by grafting seleniumcontaining molecules (phenylselenylbromide, PhSeBr) to a of Zr(IV)-based UiO-66-NH2 framework. The as-prepared UiO-66-Se systems show good catalytic activity over three cycles. The highefficiency GPx mimic metal-organic frameworks (MOFs) are endowed with excellent thermal and structural stability, providing a promising avenue for the development of artificial enzyme mimics.
https://doi.org/10.1007/s12274-017-1623-2
2018, 11(10): 5761–5768
Published: 3 October 2018