Volume 11

Issue 10,2018

(46 articles)


Sean D. Allen1, Yu-Gang Liu2, Sharan Bobbala2, Lei Cai3, Peter I. Hecker3,4, Ryan Temel3,4, and Evan A. Scott1,2 (*)

Poly (ethylene glycol)-block-poly (propylene sulfide)(PEG-bl-PPS) polymersomes formed by flash nanoprecipitation were found to be non-toxic after repeated intravenous administration in non-human primates. Polymersomes were taken up by antigen-presenting cell subsets in the liver, kidneys, and spleen of treated cynomolgus monkeys.
2018, 11(10): 5689–5703
Published: 28 April 2018

Luying Wang1,3, Pingqiang Cai4, Jing Luo2,3, Feilong Zhang1,3, Jian Liu2, Yupeng Chen2,3, Zhongpeng Zhu2,3, Yongyang Song2,3, Bingquan Yang2, Xi Liu2,3, Xiaodong Chen4, and Shutao Wang2,3 (*)

Subcellular-patterned biointerfaces were employed to inhibit the surface wetting of multicellular spheroids.
2018, 11(10): 5704–5715
Published: 22 June 2018

Wei Jiang1, Jilong Wang2, Jinbin Yang3, Zhiwei He4, Zhenhui Hou4, Yingli Luo2, Li Wang2, Jing Liu2, Houbing Zhang1, Yangyang Zhao2, Guoqing Zhang1, Fang Huang4, Xuechang Zhou3, Lifeng Yan1 (*), Xianzhu Yang5 (*), Yucai Wang2 (*), and Jun Wang5

A transactivator of transcription (TAT)-presenting nanomedicine, apart from improving tumor accumulation and cellular uptake, can simultaneously enhance tumor retention and promote nuclear translocation of the encapsulated platinum prodrugs, and thus improve therapeutic efficacy.
2018, 11(10): 5716–5734
Published: 3 October 2018

M. Zubair Iqbal1, Wenzhi Ren1, Madiha Saeed1, Tianxiang Chen1, Xuehua Ma1, Xu Yu1, Jichao Zhang2, Lili Zhang2, Aiguo Li2, and Aiguo Wu1 (*)

A unique liquid-phase method was employed to fabricate Mn3O4- TiO2/ZnO/Fe3O4 multifunctional binary transition metal oxide-based Janus nanoparticles, using the concept of epitaxial growth and lattice mismatch among synthesized materials. These multifunctional Mn3O4-TiO2 Janus nanoparticles enhance T1-weighted magnetic resonance imaging contrast in the heart, liver, and kidneys and show excellent tumor ablation in photodynamic therapy.
2018, 11(10): 5735–5750
Published: 3 October 2018

Trever Todd1,§, Zhenhui Lu2,§, Jinmin Zhao2,§, Benjamin Cline1, Weizhong Zhang1, Hongmin Chen1,3, Anil Kumar1, Wen Jiang1, Franklin West4, Samuel Franklin5, Li Zheng2 (*), and Jin Xie1 (*)

Controlled lithium delivery for efficient osteoarthritis therapy is described. We use a LiF nanocrystal as a lithium reservoir, silica coating to control the lithium release rate, and hyaluronic acid as the delivery medium. The sustained lithium release elicits broad inhibition of osteoarthritis-related catabolic markers, leading to effective protection of cartilage.
2018, 11(10): 5751–5760
Published: 14 April 2018

Weiqiang Zhou1,2, Hongfeng Li1, Bin Xia1, Wenlan Ji1, Shaobo Ji2, Weina Zhang1, Wei Huang1(*), Fengwei Huo1(*), and Huaping Xu2 (*)

A general and facile method to fabricate efficient glutathione peroxidase (GPx) mimics has been developed by grafting seleniumcontaining molecules (phenylselenylbromide, PhSeBr) to a of Zr(IV)-based UiO-66-NH2 framework. The as-prepared UiO-66-Se systems show good catalytic activity over three cycles. The highefficiency GPx mimic metal-organic frameworks (MOFs) are endowed with excellent thermal and structural stability, providing a promising avenue for the development of artificial enzyme mimics.
2018, 11(10): 5761–5768
Published: 3 October 2018